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Anticorpii heterofili sunt primii anticorpi care apar în serul pacientilor care au contactat virusul Epstein-Barr, la 1- 3 săptămâni de la debutul simptomelor, în 85-95% de cazuri. Aceşti。

Anticorpii heterofili sunt absenti in 10-20% din cazurile de mononucleoza infectioasa la adult, procentul fiind mai mare la copiii cu infectie manifesta. In aceste sianticorpi heterofilituatii, confirmarea。

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